谷胱甘肽

称谓

谷胱甘肽 glutathione r-glutamyl cysteingl +glycine GSH

生理作用

人体最厉害的抗氧化剂。 [[应对氨氮：合成谷胱甘肽]]

解毒

组成

• [[0. 谷氨酸（Glu，麸氨酸，glutamate）]]

• [[C3：半胱氨酸（Cys；cysteine）]]

• [[C2：甘氨酸（Gly，glycine）]]

-

\usepackage{chemfig}
\begin{document}

%% γ谷氨酸a
\definesubmol\gamaglu{
	(-[::150]HOOC)
	(<:[::-90]NH_{2})
	-[::30]-[::-60]-[::60](=[::60]O)
}

%% 半胱氨酸b
\definesubmol\cysb{
N
	(-[::-60,0.3,,,transparent]H)
	-[::60]
		(<[::60]-[::60]HS
			(-[2,0.5,,,transparent]) % 上边缘支撑
		)
	-[::-60]
		(=[::-60]O)
}

%% 甘氨酸a
\definesubmol\glya{
N
	(-[::60,0.3,,,transparent]H)
	-[::-60]
		(-[::-60]H
		)
	-[::60]
		(=[::60]O
			-[2,0.5,,,transparent] % 上边缘支撑
		)
}

\chemfig{
	!\gamaglu
	-[::-60]!\cysb
	-[::+60]!\glya
	-[::-60]!OH
}
\end{document}

^5-1

-

\usepackage{chemfig}
\begin{document}

%% γ谷氨酸a
\definesubmol\gamaglu{
	(-[::150]HOOC)
	(<:[::-90]NH_{2})
	-[::30,,,,green]
	-[::-60,,,,blue]-[::60,,,,blue](=[::60,,,,blue]O)
}

%% 半胱氨酸b
\definesubmol\cysb{
N
	(-[::-60,0.3,,,transparent]H)
	-[::60]
		(<[::60,,,,green]-[::60,,,,green]\textcolor{Orange}{HS}
			(-[2,0.5,,,transparent]) % 上边缘支撑
		)
	-[::-60]
		(=[::-60]O)
}

%% 甘氨酸a
\definesubmol\glya{
N
	(-[::+60,0.3,,,,transparent]H)
	-[::-60]
		(-[::-60,,,,green]\textcolor{green}{H}
		)
	-[::60]
		(=[::60]O
			-[2,0.5,,,transparent] % 上边缘支撑
		)
}

\chemfig{
!\gamaglu
	-[::-60]!\cysb
	-[::+60]!\glya
	-[::-60]!OH
}
\end{document}

^5-2

---

• 错的，应该连谷氨酸R基上的羧基

\usepackage{chemfig}
\begin{document}

%% 谷氨酸a
\definesubmol\glua{
N
	(-[::+60,0.3,,,,transparent]H)
	-[::-60]
		(<:[::-60]-[::60]-[::-60]
			(-[::60]OH)
			(=[::-60]O)
		)
	-[::60]
		(=[::60]O)
}

%% 半胱氨酸b
\definesubmol\cysb{
N
	(-[::-60,0.3,,,transparent]H)
	-[::60]
		(<[::60]-[::60]HS
			(-[2,0.5,,,transparent]) % 上边缘支撑
		)
	-[::-60]
		(=[::-60]O)
}

%% 甘氨酸a
\definesubmol\glya{
N
	(-[::60,0.3,,,transparent]H)
	-[::-60]
		(-[::-60]H
		)
	-[::60]
		(=[::60]O
			-[2,0.5,,,transparent] % 上边缘支撑
		)
}

\chemfig{
H
	-[::+30]!\glua
	-[::-60]!\cysb
	-[::+60]!\glya
	-[::-60]!OH
}
\end{document}

^5-1-2

• 错的，应该连谷氨酸R基上的羧基

\usepackage{chemfig}
\begin{document}

%% 谷氨酸a
\definesubmol\glua{
N
	(-[::+60,0.3,,,,transparent]H)
	-[::-60]
		(<:[::-60,,,,green]-[::60,,,,red]-[::-60,,,,red]
			(-[::60,,,,red]\textcolor{red}{OH})
			(=[::-60,,,,red]\textcolor{red}{O})
		)
	-[::60]
		(=[::60]O)
}

%% 半胱氨酸b
\definesubmol\cysb{
N
	(-[::-60,0.3,,,transparent]H)
	-[::60]
		(<[::60,,,,green]-[::60,,,,green]\textcolor{Orange}{HS}
			(-[2,0.5,,,transparent]) % 上边缘支撑
		)
	-[::-60]
		(=[::-60]O)
}

%% 甘氨酸a
\definesubmol\glya{
N
	(-[::+60,0.3,,,,transparent]H)
	-[::-60]
		(-[::-60,,,,green]\textcolor{green}{H}
		)
	-[::60]
		(=[::60]O
			-[2,0.5,,,transparent] % 上边缘支撑
		)
}

\chemfig{
H
	-[::+30]!\glua
	-[::-60]!\cysb
	-[::+60]!\glya
	-[::-60]!OH
}
\end{document}

^5-2-2

前体

[[N-乙酰半胱氨酸（NAC）]] [[C2：甘氨酸（Gly，glycine）]]