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辅酶A

coenzyme A smiles CC C COP =O O OP =O O OC C@@H 1 C@H C@H C@@H O1 N2C=NC3=C N=CN=C32 N O OP =O O O C@H C =O NCCC =O NCCS O $结构式：$ - CoA-SH - HSCoA - P205 tikz \usepackage

作者：admin

2026-08-16

称谓

coenzyme A

3D结构

CC(C)(COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)[C@H](C(=O)NCCC(=O)NCCS)O

结构

$结构式：$ - CoA-SH

- HSCoA

• P205

\usepackage{chemfig}
\begin{document}
\chemfig[atom sep=2em,cram width=2pt]{
% β-巯基乙胺（2-Mercaptoethylamine）
{\color{orange}HS}-CH_2-CH_2-NH
% 泛酸
	% β-Ala
	-C(=[2,,,,]O)-CH_2-CH_2-NH_2
	% 泛解酸
	-C(=[2,,]O)-CH(-[6,]OH)-C(-[2,]CH_3)(-[6,]CH_3)-CH_2-O
	% 焦磷酸（Pantothenate）
	-P
		(=[2,]O)
		(-[6,]OH)
	-O-P
		(=[2,]O)
		(-[6,]OH)
	-O-CH_2-[6,]
% 3'-磷酸腺苷
    (-[6,]H)
	(-[0.75,1.2]O)
	<[6.75,]
	(-[6,1]O-[6,]P
		(=[6,]O)
		(-[4,]HO)
		(-[,]OH)
	)
	(-[2,0.8]H)
	-[,,,, line width=2pt]
	(-[6,]OH)(-[2,0.8]H)>[1.25,](-[3.25,])
	(-[6,]H)(-[2,]N
		*5(-(
			*6(-N=-N=(-[2.4,,,1]NH_2
				-[2,0.5,,,,transparent] %上边界支撑
			)-=)
		)--N=-)
	)
}
\end{document}

• P205

\usepackage{chemfig}
\begin{document}
\chemfig[atom sep=2em,cram width=2pt]{
% β-巯基乙胺（2-Mercaptoethylamine）
{\color{orange}HS}-CH_2-CH_2-NH
% 泛酸
	% 丙氨酸
	-C(=[2,,]O)-CH_2-CH_2-NH_2
	% 泛解酸
	-C(=[2,,]O)-CH(-[6,]OH)-C(-[2,]CH_3)(-[6,]CH_3)-CH_2-O
	% 焦磷酸（Pantothenate）
	-P
		(=[2,]O)
		(-[6,]OH)
	-O-P
		(=[2,]O)
		(-[6,]OH)
	-O-CH_2-[6,]
% 3磷酸腺苷
    (-[6,]H)
	(-[0.75,1.2]O)
	<[6.75,]
	(-[6,1]O-[6,]P
		(=[6,]O)
		(-[4,]HO)
		(-[,]OH)
	)
	(-[2,0.8]H)
	-[,,,, line width=2pt]
	(-[6,]OH)(-[2,0.8]H)>[1.25,](-[3.25,])
	(-[6,]H)(-[2,]N
		*5(-(
			*6(-N=-N=(-[2.4,,,1]NH_2
				-[2,0.5,,,,transparent] %上边界支撑
			)-=)
		)--N=-)
	)
}
\end{document}

• P205

\usepackage{chemfig}
\begin{document}
\chemfig[atom sep=2em,cram width=2pt]{
% β-巯基乙胺（2-Mercaptoethylamine）
{\color{orange}HS}-[1,]-[7,]-[1,]NH
% 泛酸
-[7,,1](=[6,]O)-[1,]-[7,]-[1,]NH-[7,,1](=[6,]O)-[1,](-[2,]OH)-[7,](-[5,])(-[7,])-[1,]-[7,]O
% 焦磷酸（Pantothenate）
-P
	(=[2,]O)
	(-[6,]OH)
-O-P
	(=[2,]O)
	(-[6,]OH)
-O--[6,]
% 3磷酸腺苷
    (-[6,]H)
	(-[0.75,1.2]O)
	<[6.75,]
	(-[6,1]O-[6,]P
		(=[6,]O)
		(-[4,]HO)
		(-[,]OH)
	)
	(-[2,0.8]H)
	-[,,,, line width=2pt]
	(-[6,]OH)(-[2,0.8]H)>[1.25,](-[3.25,])
	(-[6,]H)(-[2,]N
		*5(-(
			*6(-N=-N=(-[2.4,,,1]NH_2
				-[2,0.5,,,,transparent] %上边界支撑
			)-=)
		)--N=-)
	)
}
\end{document}

• P205

\usepackage{chemfig}
\begin{document}
\chemfig[atom sep=2em,cram width=2pt]{
% β-巯基乙胺（2-Mercaptoethylamine）
HS-[1,]-[7,]-[1,]NH
% 泛酸
-[7,,1](=[6,]O)-[1,]-[7,]-[1,]NH-[7,,1](=[6,]O)-[1,](-[2,]OH)-[7,](-[5,])(-[7,])-[1,]-[7,]O
% 焦磷酸（Pantothenate）
-P
	(=[2,]O)
	(-[6,]OH)
-O-P
	(=[2,]O)
	(-[6,]OH)
-O--[6,]
% 3磷酸腺苷
    (-[6,]H)
	(-[0.75,1.2]O)
	<[6.75,]
	(-[6,1]O-[6,]P
		(=[6,]O)
		(-[4,]HO)
		(-[,]OH)
	)
	(-[2,0.8]H)
	-[,,,, line width=2pt]
	(-[6,]OH)(-[2,0.8]H)>[1.25,](-[3.25,])
	(-[6,]H)(-[2,]N
		*5(-(
			*6(-N=-N=(-[2.4,,,1]NH_2
				-[2,0.5,,,,transparent] %上边界支撑
			)-=)
		)--N=-)
	)
}
\end{document}

\usepackage{chemfig}
\begin{document}
\chemfig[atom sep=2em,cram width=2pt]{
% β-巯基乙胺
HS-[1,]-[7,]-[1,]NH
% 泛酸
-[7,,1](=[6,]O)-[1,]-[7,]-[1,]NH-[7,,1](=[6,]O)-[1,](-[2,]OH
	-[2,0.5,,,,transparent] %上边界支撑
)-[7,](-[5,])(-[7,])-[1,]-[7,]O
% 焦磷酸
-P
	(=[2,]O)
	(-[6,]OH)
-O-P
	(=[2,]O)
	(-[6,]OH)
-O--[6,]
% 3磷酸腺苷
    (-[6,]H)
	(-[0.75,1.2]O)
	<[6.75,](-[6,]\fbox{P})(-[2,0.8]H)
	-[,,,, line width=2pt]
	(-[6,]OH)(-[2,0.8]H)>[1.25,](-[3.25,])
	(-[6,]H)(-[2,]A)
}
\end{document}

--- -

\usepackage{chemfig}
\begin{document}
\chemfig{
HS-[1,0.6]-[7,0.6]-[1,0.6]N(-[2,0.3]H)-[7,0.6](=[6,0.6]O)-[1,0.6]-[7,0.6]-[1,0.6]N(-[2,0.3]H)-[7,0.6](=[6,0.6]O)-[1,0.6](-[2,0.6]OH
	-[2,0.5,,,,transparent] %上边界支撑
)-[7,0.6](-[5,0.6])(-[7,0.6])-[1,0.6]-[7,0.6]O-[,0.6]P(=[2,0.6]O)(-[,0.6]O-[,0.6]P(=[2,0.6]O)(-[,0.6]O-[,0.6]-[6,0.6]
    (-[6,0.6]H)
	(-[0.75,0.8]O)
	<[6.75,0.7](-[6,1]\fbox{P})(-[2,0.5]H)
	-[,0.5,,, line width=2pt]
	(-[6,0.5]OH)(-[2,0.5]H)>[1.25,0.7](-[3.25,0.6])
	(-[6,0.6]H)-[2,0.4]A)(-[6,0.6]OH))(-[6,0.6]OH)
}
\end{document}

\usepackage{chemfig}
\begin{document}
\chemfig{
HS-[1,0.6]-[7,0.6]-[1,0.6]N(-[2,0.3]H)-[7,0.6](=[6,0.6]O)-[1,0.6]-[7,0.6]-[1,0.6]N(-[2,0.3]H)-[7,0.6](=[6,0.6]O)-[1,0.6](-[2,0.6]OH
	-[2,0.5,,,,transparent] %上边界支撑
)-[7,0.6](-[5,0.6])(-[7,0.6])-[1,0.6]-[7,0.6]O-[,0.6]P(=[2,0.6]O)(-[,0.6]O-[,0.6]P(=[2,0.6]O)(-[,0.6]O-[,0.6]-[6,0.6]
    (-[6,0.6]H)
	(-[0.75,0.8]O)
	<[6.75,0.7](-[6,1]OPO_3^{2-})(-[2,0.5]H)
	-[,0.5,,, line width=2pt]
	(-[6,0.5]OH)(-[2,0.5]H)>[1.25,0.7](-[3.25,0.6])
	(-[6,0.6]H)-[2,0.4]A)(-[6,0.6]OH))(-[6,0.6]OH)
}
\end{document}

\usepackage{chemfig}
\begin{document}
\chemfig{
HS-[1,0.6]-[7,0.6]-[1,0.6]N(-[2,0.3]H)-[7,0.6](=[6,0.6]O)-[1,0.6]-[7,0.6]-[1,0.6]N(-[2,0.3]H)-[7,0.6](=[6,0.6]O)-[1,0.6](-[2,0.6]OH)-[7,0.6](-[5,0.6])(-[7,0.6])-[1,0.6]-[7,0.6]O-[,0.6]P(=[2,0.6]O)(-[,0.6]O-[,0.6]P(=[2,0.6]O)(-[,0.6]O-[,0.6]-[6,0.6]
    (-[6,0.6]H)
	(-[0.75,0.8]O)
	<[6.75,0.7](-[6,1]OPO_3^{2-})(-[2,0.5]H)
	-[,0.5,,, line width=2pt]
	(-[6,0.5]OH)(-[2,0.5]H)>[1.25,0.7](-[3.25,0.6])
	(-[6,0.6]H)-[2,0.4]N
(-[0.25,0.5]
	(-[7.5,0.5]N=[0.5,0.5]-[2,0.5]N=[3.5,0.5](-[2,0.5]NH_2
		-[2,0.5,,,,transparent] %上边界支撑
	)-[4.5,0.5]
	(-[3.5,0.5]N=[5,0.6]-[7,0.3])
	=[6,0.5])))(-[6,0.6]OH))(-[6,0.6]OH)
}
\end{document}

O=C(NCCS)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3OP(=O)(O)O

CC(C)(CO[P](O)(=O)O[P](O)(=O)OC[CH]1O[CH]([CH](O)[CH]1O[P](O)(O)=O)n2cnc3c(N)ncnc23)[CH](O)C(=O)NCCC(=O)NCCS

CC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)n2cnc3c2ncnc3N)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCS)O

组成

• [[β-巯基乙胺（2-Mercaptoethylamine）]]

• [[0. 维生素B5：泛酸（Pantothenic acid）]]

• 带有【3‘磷酸基团】的[[ADP：二磷酸腺苷]]

辅基

[[辅基：磷酸泛酰巯基乙胺]] [[0. A：腺嘌呤（adenine）]]