跳到正文
学而记

百科词条

HK：催化反应1--葡萄糖磷酸化

HkC1Scene.mp4 - 细胞捕获葡萄糖 葡萄糖身上加一个磷酸基团就不能穿过细胞膜了。 上面这句话不准确。因为 C6：葡萄糖（glucose） 也不能自由穿细胞膜，而是通过 0. 葡萄糖转运体（GLUT） 。 C6：葡萄糖（glucose） +ATP= C6：葡糖-6-磷酸（glucose 6-phosphate，G6P） +ADP $化学方程式：$

作者：admin

![[HkC1Scene.mp4]]

生物学作用

• 细胞捕获葡萄糖

> 葡萄糖身上加一个磷酸基团就不能穿过细胞膜了。

上面这句话不准确。因为[[C6：葡萄糖（glucose）]]也不能自由穿细胞膜，而是通过[[0. 葡萄糖转运体（GLUT）]]。

反应过程

[[C6：葡萄糖（glucose）]]+ATP=[[C6：葡糖-6-磷酸（glucose 6-phosphate，G6P）]]+ADP

$化学方程式：$ -

\usepackage{chemfig}
\definecolor{cpk_P}{rgb}{1.00, 0.50, 0.00}     % P
\begin{document}
\chemname{
\chemfig[cram width=2pt]{
	%[:-30]
	%C4
	(-[2,0.5]H)(-[6,0.5,,2]HO)
	*6(
	%C3
	<(-[6,0.5]H)(-[2,0.5]OH)
	%C2
	-[,1,,, line width=2pt](-[2,0.5]H)(-[6,0.5]OH)
	%C1
	>(-[2,0.5]H)(-[6,0.5]OH)
	-O-
	(-[2,0.5,,3]HOCH_2)-
	)
}
}{glucose}
+

\color{cpk_P}ATP\color{black}

\begin{tikzpicture} 
\draw [->] (0,0) to node[above] {hexokinase;^{2+}$} (2.8,0);
\end{tikzpicture}
\chemname{
\chemfig[cram width=2pt]{
	%[:-30]
	%C4
	(-[2,0.5]H)(-[6,0.5,,2]HO)
	*6(
	%C3
	<(-[6,0.5]H)(-[2,0.5]OH)
	%C2
	-[,1,,, line width=2pt](-[2,0.5]H)(-[6,0.5]OH)
	%C1
	>(-[2,0.5]H)(-[6,0.5]OH)
	-O-
	%C5
	(-[2,0.5,,]CH_2O
				% P
				(-[0,0.35,,,,transparent]{\chemmove{\draw[ultra thick,green,fill=cpk_P,line width=2pt] (0.1,0.12)circle(6pt);}P}
				% 上边界支撑
				-[2,0.5,,,,transparent])
	)-
	)
}
}{glucose 6-phosphate}
+ADP
\end{document}

^1

-

\usepackage{chemfig}
\definecolor{cpk_P}{rgb}{1.00, 0.50, 0.00}     % P
\begin{document}
\chemname{
\chemfig[cram width=2pt]{
	%[:-30]
	%C4
	(-[2,0.5]H)(-[6,0.5,,2]HO)
	*6(
	%C3
	<(-[6,0.5]H)(-[2,0.5]OH)
	%C2
	-[,1,,, line width=2pt](-[2,0.5]H)(-[6,0.5]OH)
	%C1
	>(-[2,0.5]H)(-[6,0.5]OH)
	-O-
	(-[2,0.5,,3]HOCH_2)-
	)
}
}{}
+

\chemfig[atom sep=2em]{
-[2,.1,,,transparent] %向上支撑
		% P
		(-[0,0.54,,,,transparent]{\chemmove{\draw[ultra thick,green,fill=cpk_P,line width=2pt] (0.1,0.12)circle(6pt);}P}
			% 下边界支撑
			-[6,0.5,,,,transparent]
		)
}

\begin{tikzpicture} 
\draw [->] (0,0) to node[above] {} (1,0);
\end{tikzpicture}

\chemname{
\chemfig[cram width=2pt]{
	%[:-30]
	%C4
	(-[2,0.5]H)(-[6,0.5,,2]HO)
	*6(
	%C3
	<(-[6,0.5]H)(-[2,0.5]OH)
	%C2
	-[,1,,, line width=2pt](-[2,0.5]H)(-[6,0.5]OH)
	%C1
	>(-[2,0.5]H)(-[6,0.5]OH)
	-O-
	%C5
	(-[2,0.5,,]CH_2O
				% P
				(-[0,0.35,,,,transparent]{\chemmove{\draw[ultra thick,green,fill=cpk_P,line width=2pt] (0.1,0.12)circle(6pt);}P}
				% 上边界支撑
				-[2,0.5,,,,transparent])
	)-
	)
}
}{}
+$

\end{document}

^2

-

\usepackage{chemfig}
\begin{document}
\chemname{
\chemfig[cram width=2pt]{
	%[:-30]
	%C4
	(-[2,0.5]H)(-[6,0.5,,2]HO)
	*6(
	%C3
	<(-[6,0.5]H)(-[2,0.5]OH)
	%C2
	-[,1,,, line width=2pt](-[2,0.5]H)(-[6,0.5]OH)
	%C1
	>(-[2,0.5]H)(-[6,0.5]OH)
	-O-
	(-[2,0.5,,3]HOCH_2)-
	)
}
}{glucose}
+ATP
\begin{tikzpicture} 
\draw [->] (0,0) to node[above] {hexokinase;^{2+}$} (2.8,0);
\end{tikzpicture}
\chemname{
\chemfig[cram width=2pt]{
	%[:-30]
	%C4
	(-[2,0.5]H)(-[6,0.5,,2]HO)
	*6(
	%C3
	<(-[6,0.5]H)(-[2,0.5]OH)
	%C2
	-[,1,,, line width=2pt](-[2,0.5]H)(-[6,0.5]OH)
	%C1
	>(-[2,0.5]H)(-[6,0.5]OH)
	-O-
	%C5
	(-[2,0.5,,5]^{2-}O_3POCH_2)-
	)
}
}{glucose 6-phosphate}
+ADP
\end{document}

-

\usepackage{chemfig}
\begin{document}
\chemfig{
	(-[,0.5]OH)
	(<[5,0.5]
		(-[7,0.5]OH)
		(-[4,0.5,,, line width=2pt]
			(-[5,0.5]HO)
			(>[3,0.5]
				(-[4,0.5]HO)
				(-[1,0.5]
					(-[2,0.5]
						(-[3.5,0.8]HO)
					)
					(-[,0.5]O
						(-[7,0.5])
					)
				)
			)
		)
	)
}
+ATP
\begin{tikzpicture} 
\draw [->] (0,0) to node[above] {HK;^{2+}$} (1.6,0);
\end{tikzpicture}

\chemfig{
	(-[,0.5]OH)
	(<[5,0.5]
		(-[7,0.5]OH)
		(-[4,0.5,,, line width=2pt]
			(-[5,0.5]HO)
			(>[3,0.5]
				(-[4,0.5]HO)
				(-[1,0.5]
					(-[2,0.5]
						(-[3.5,0.8]\fbox{P})
					)
					(-[,0.5]O
						(-[7,0.5])
					)
				)
			)
		)
	)
}

+ADP
\end{document}

逆反应

[[葡萄糖-6-磷酸酶（g6pase）]]