0. 磷酸己糖异构酶（phosphohexose isomerase；PHI）--葡萄糖-6-磷酸异构化

![[PhiScene.mp4]]

称谓

磷酸己糖异构酶 phosphohexose isomerase PHI 磷酸葡萄糖异构酶

催化反应

[[C6：葡糖-6-磷酸（glucose 6-phosphate，G6P）]]<->[[C6：果糖-6-磷酸（F6P）]]

$化学方程式：$

-

\usepackage{chemfig}
\definecolor{cpk_P}{rgb}{1.00, 0.50, 0.00}     % P
\begin{document}
\chemname{
\chemfig[cram width=2pt]{
	%[:-30]
	%C4
	(-[2,0.5]H)(-[6,0.5,,2]HO)
	*6(
	%C3
	<(-[6,0.5]H)(-[2,0.5]OH)
	%C2
	-[,1,,, line width=2pt](-[2,0.5]H)(-[6,0.5]OH)
	%C1
	>(-[2,0.5]H)(-[6,0.5]OH)
	-O-
	%C5
	(-[2,0.5,,]CH_2O
				% P
				(-[0,0.35,,,,transparent]{\chemmove{\draw[ultra thick,green,fill=cpk_P,line width=2pt] (0.1,0.12)circle(6pt);}P}
				% 上边界支撑
				-[2,0.5,,,,transparent])
	)-
	)
}
}{glucose 6-phosphate}
\begin{tikzpicture} 
\draw [<->] (0,0) to node[above] {phosphohexose isomerase;^{2+}$} (5,0); 
\end{tikzpicture}
\chemname{
\chemfig[cram width=2pt]{
	%5-6
		(-[6,0.5]H)
		(-[0.7,1.25]O)
			%6
			(-[2,1.25,,]CH_2O
				% P
				(-[0,0.35,,,,transparent]{\chemmove{\draw[ultra thick,green,fill=cpk_P,line width=2pt] (0.1,0.12)circle(6pt);}P}
				% 上边界支撑
				-[2,0.5,,,,transparent])
			)
	%4
	<[6.75,](-[6,0.5]OH)(-[2,0.5]H)
	%3
	-[,,,, line width=2pt](-[2,0.5,,2]HO)(-[6,0.5]H)
	%2
    >[1.25,](-[2,0.5]OH)(-[3.3,1.05])
	%1
	-[6,0.5]CH_2OH
}
}{fructose 6-phosphate}
\end{document}

^1

-

\usepackage{chemfig}
\definecolor{cpk_P}{rgb}{1.00, 0.50, 0.00}     % P
\begin{document}
\chemname{
\chemfig[cram width=2pt]{
	%[:-30]
	%C4
	(-[2,0.5]H)(-[6,0.35,,]-[6,0.15,,,transparent]-[4,0.13,,,transparent]{\color{pink}HO})
	*6(
	%C3
	<(-[6,0.5]H)(-[2,0.35]-[2,0.15,,,transparent]-[0,0.13,,,transparent]{\color{blue}OH})
	%C2
	-[,1,,, line width=2pt](-[2,0.5]H)(-[6,0.35]-[6,0.15,,,transparent]-[0,0.13,,,transparent]{\color{green}OH})
	%C1
	>(-[2,0.5]H)(-[6,0.35]-[6,0.15,,,transparent]-[0,0.15,,,transparent]{\color{red}OH})
	-O-
	%C5
	(-[2,0.5,,]CH_2O
				% P
				(-[0,0.35,,,,transparent]{\chemmove{\draw[ultra thick,green,fill=cpk_P,line width=2pt] (0.1,0.12)circle(6pt);}P}
				% 上边界支撑
				-[2,0.5,,,,transparent])
	)-
	)
}
}{}
\begin{tikzpicture} 
\draw [<->] (0,0) to node[above] {} (1,0); 
\end{tikzpicture}
\chemname{
\chemfig[cram width=2pt]{
	%5-6
		(-[6,0.5]H)
		(-[0.7,1.25]O)
			%6
			(-[2,1.25,,]CH_2O
				% P
				(-[0,0.35,,,,transparent]{\chemmove{\draw[ultra thick,green,fill=cpk_P,line width=2pt] (0.1,0.12)circle(6pt);}P}
				% 上边界支撑
				-[2,0.5,,,,transparent])
			)
	%4
	<[6.75,](-[6,0.35]-[6,0.15,,,transparent]-[0,0.13,,,transparent]{\color{pink}OH})(-[2,0.5]H)
	%3
	-[,,,, line width=2pt](-[2,0.35,,]-[2,0.15,,,transparent]-[4,0.13,,,transparent]{\color{blue}HO})(-[6,0.5]H)
	%2
    >[1.25,](-[2,0.35]-[2,0.15,,,transparent]-[0,0.13,,,transparent]{\color{green}OH})(-[3.3,1.05])
	%1
	-[6,0.5]CH_2{\color{red}OH}
}
}{}
\end{document}

^2

-

\usepackage{chemfig}
\begin{document}
\chemname{
\chemfig[cram width=2pt]{
	%[:-30]
	%C4
	(-[2,0.5]H)(-[6,0.5,,2]HO)
	*6(
	%C3
	<(-[6,0.5]H)(-[2,0.5]OH)
	%C2
	-[,1,,, line width=2pt](-[2,0.5]H)(-[6,0.5]OH)
	%C1
	>(-[2,0.5]H)(-[6,0.5]OH)
	-O-
	%C5
	(-[2,0.5,,5]^{2-}O_3POCH_2)-
	)
}
}{glucose 6-phosphate}
\begin{tikzpicture} 
\draw [<->] (0,0) to node[above] {phosphohexose isomerase;^{2+}$} (5,0); 
\end{tikzpicture}
\chemname{
\chemfig[cram width=2pt]{
	%5-6
	(-[6,0.5]H)(-[0.7,1.25]O)(-[2,,,5]^{2-}O_3POCH_2)
	%4
	<[6.75,](-[6,0.5]OH)(-[2,0.5]H)
	%3
	-[,,,, line width=2pt](-[2,0.5,,2]HO)(-[6,0.5]H)
	%2
    >[1.25,](-[2,0.5]OH)(-[3.3,1.05])
	%1
	-[6,0.5]CH_2OH
}
}{fructose 6-phosphate}
\end{document}

-

\usepackage{chemfig}
\begin{document}

\chemfig{
	(-[,0.5]OH)
	(<[5,0.5]
		(-[7,0.5]OH)
		(-[4,0.5,,, line width=2pt]
			(-[5,0.5]HO)
			(>[3,0.5]
				(-[4,0.5]HO)
				(-[1,0.5]
					(-[2,0.5]
						(-[3.5,0.8]\fbox{P})
					)
					(-[,0.5]O
						(-[7,0.5])
					)
				)
			)
		)
	)
}

\begin{tikzpicture} 
\draw [<->] (0,0) to node[above] {PHI;^{2+}$} (1.8,0); 
\end{tikzpicture}

\chemfig{
	(-[2,0.5]OH)
	(>[5,0.5]
		(-[3,0.6])
		(<:[7.5,0.8]OH)
		(-[5,0.5]
			(<[7,0.8]OH)
			(-[4,0.5]
				(<:[5,0.8]HO)
				(-[3,0.5]
					(-[1,0.85]O)
					(<[3,0.5]
						(-[2,0.5]\fbox{P})
					)
				)
			)
		)
	)
}

\end{document}