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0. 磷酸果糖激酶-1（PFK-1）--果糖-6-磷酸磷酸化

Pfk1Scene.mp4 磷酸果糖激酶1 6-磷酸果糖激酶 phosphofructokinase-1 PFK-1 C6：果糖-6-磷酸（F6P） +ATP- C6：果糖-1,6-二磷酸（FBP） +ADP $化学方程式：$ - tikz \usepackage chemfig \definecolor cpk P rgb 1.00, 0.50, 0

作者：admin

![[Pfk1Scene.mp4]]

称谓

磷酸果糖激酶1 6-磷酸果糖激酶 phosphofructokinase-1 PFK-1

催化反应

[[C6：果糖-6-磷酸（F6P）]]+ATP->[[C6：果糖-1,6-二磷酸（FBP）]]+ADP

$化学方程式：$ -

\usepackage{chemfig}
\definecolor{cpk_P}{rgb}{1.00, 0.50, 0.00}     % P
\definecolor{cpk_P6}{rgb}{0.50, 0.75, 0.50}     % P6
\begin{document}
\chemname{
\chemfig[cram width=2pt]{
	%5-6
		(-[6,0.5]H)
		(-[0.7,1.25]O)
			%6
			(-[2,1.25,,]CH_2O
				% P
				(-[0,0.35,,,,transparent]{\chemmove{\draw[ultra thick,green,fill=cpk_P,line width=2pt] (0.1,0.12)circle(6pt);}P}
				% 上边界支撑
				-[2,0.5,,,,transparent])
			)
	%4
	<[6.75,](-[6,0.5]OH)(-[2,0.5]H)
	%3
	-[,,,, line width=2pt](-[2,0.5,,2]HO)(-[6,0.5]H)
	%2
    >[1.25,](-[2,0.5]OH)(-[3.3,1.05])
	%1
	-[6,0.5]CH_2OH
}
}{fructose 6-phosphate}
+\color{cpk_P6}ATP\color{black}
\begin{tikzpicture} 
\draw [->] (0,0) to node[above] {phosphofructokinase-1;^{2+}$} (4.6,0); 
\end{tikzpicture}
\chemname{
\chemfig[cram width=2pt]{
	%5-6
	(-[6,0.5]H)(-[0.7,1.25]O)(-[2,1.25]CH_2O
				% P
				(-[0,0.35,,,,transparent]{\chemmove{\draw[ultra thick,green,fill=cpk_P,line width=2pt] (0.1,0.12)circle(6pt);}P}
				% 上边界支撑
				-[2,0.5,,,,transparent])
	)
	%4
	<[6.75,](-[6,0.5]OH)(-[2,0.5]H)
	%3
	-[,,,, line width=2pt](-[2,0.5,,2]HO)(-[6,0.5]H)
	%2
    >[1.25,](-[2,0.5]OH)(-[3.3,1.05])
	%1
	-[6,0.5]CH_2O
		% P
		(-[0,0.35,,,,transparent]{\chemmove{\draw[ultra thick,green,fill=cpk_P6,line width=2pt] (0.1,0.12)circle(6pt);}P})
}
}{fructose 1,6-bisphosphate}
+ADP
\end{document}

^1

-

\usepackage{chemfig}
\definecolor{cpk_P}{rgb}{1.00, 0.50, 0.00}     % P
\definecolor{cpk_P6}{rgb}{0.50, 0.75, 0.50}     % P6
\begin{document}
\chemname{
\chemfig[cram width=2pt]{
	%5-6
		(-[6,0.5]H)
		(-[0.7,1.25]O)
			%6
			(-[2,1.25,,]CH_2O
				% P
				(-[0,0.35,,,,transparent]{\chemmove{\draw[ultra thick,green,fill=cpk_P,line width=2pt] (0.1,0.12)circle(6pt);}P}
				% 上边界支撑
				-[2,0.5,,,,transparent])
			)
	%4
	<[6.75,](-[6,0.5]OH)(-[2,0.5]H)
	%3
	-[,,,, line width=2pt](-[2,0.5,,2]HO)(-[6,0.5]H)
	%2
    >[1.25,](-[2,0.5]OH)(-[3.3,1.05])
	%1
	-[6,0.5]CH_2OH
}
}{}
+
\chemfig[atom sep=2em]{
-[2,.1,,,transparent] %向上支撑
		% P
		(-[0,0.54,,,,transparent]{\chemmove{\draw[ultra thick,green,fill=cpk_P6,line width=2pt] (0.1,0.12)circle(6pt);}P})
}
\begin{tikzpicture} 
\draw [->] (0,0) to node[above] {} (1,0); 
\end{tikzpicture}
\chemname{
\chemfig[cram width=2pt]{
	%5-6
	(-[6,0.5]H)(-[0.7,1.25]O)(-[2,1.25]CH_2O
				% P
				(-[0,0.35,,,,transparent]{\chemmove{\draw[ultra thick,green,fill=cpk_P,line width=2pt] (0.1,0.12)circle(6pt);}P}
				% 上边界支撑
				-[2,0.5,,,,transparent])
	)
	%4
	<[6.75,](-[6,0.5]OH)(-[2,0.5]H)
	%3
	-[,,,, line width=2pt](-[2,0.5,,2]HO)(-[6,0.5]H)
	%2
    >[1.25,](-[2,0.5]OH)(-[3.3,1.05])
	%1
	-[6,0.5]CH_2O
		% P
		(-[0,0.35,,,,transparent]{\chemmove{\draw[ultra thick,green,fill=cpk_P6,line width=2pt] (0.1,0.12)circle(6pt);}P})
}
}{}
+$
\end{document}

^2

-

\usepackage{chemfig}
\begin{document}
\chemname{
\chemfig[cram width=2pt]{
	%5-6
	(-[6,0.5]H)(-[0.7,1.25]O)(-[2,,,5]^{2-}O_3POCH_2)
	%4
	<[6.75,](-[6,0.5]OH)(-[2,0.5]H)
	%3
	-[,,,, line width=2pt](-[2,0.5,,2]HO)(-[6,0.5]H)
	%2
    >[1.25,](-[2,0.5]OH)(-[3.3,1.05])
	%1
	-[6,0.5]CH_2OH
}
}{fructose 6-phosphate}
+ATP
\begin{tikzpicture} 
\draw [->] (0,0) to node[above] {phosphofructokinase-1;^{2+}$} (4.6,0); 
\end{tikzpicture}
\chemname{
\chemfig[cram width=2pt]{
	%5-6
	(-[6,0.5]H)(-[0.7,1.25]O)(-[2,,,5]^{2-}O_3POCH_2)
	%4
	<[6.75,](-[6,0.5]OH)(-[2,0.5]H)
	%3
	-[,,,, line width=2pt](-[2,0.5,,2]HO)(-[6,0.5]H)
	%2
    >[1.25,](-[2,0.5]OH)(-[3.3,1.05])
	%1
	-[6,0.5]CH_2OPO_3^{2-}
}
}{fructose 1,6-bisphosphate}
+ADP
\end{document}

-

\usepackage{chemfig}
\begin{document}

\chemfig{
	(-[2,0.5]OH)
	(>[5,0.5]
		(-[3,0.6])
		(<:[7.5,0.8]OH)
		(-[5,0.5]
			(<[7,0.8]OH)
			(-[4,0.5]
				(<:[5,0.8]HO)
				(-[3,0.5]
					(-[1,0.85]O)
					(<[3,0.5]
						(-[2,0.5]\fbox{P})
					)
				)
			)
		)
	)
}
+ATP

\begin{tikzpicture} 
\draw [->] (0,0) to node[above] {PFK-1;^{2+}$} (2.2,0); 
\end{tikzpicture}

\chemfig{
	(-[2,0.5]\fbox{P})
	(>[5,0.5]
		(-[3,0.6])
		(<:[7.5,0.8]OH)
		(-[5,0.5]
			(<[7,0.8]OH)
			(-[4,0.5]
				(<:[5,0.8]HO)
				(-[3,0.5]
					(-[1,0.85]O)
					(<[3,0.5]
						(-[2,0.5]\fbox{P})
					)
				)
			)
		)
	)
}
+ADP

\end{document}

逆反应

[[果糖二磷酸酶（FBP）]]